SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms.
Veterinary medicine maker Zoetis Inc. said Monday that recently approved Sileo will be available through veterinarians within a week. It’s a much-needed option for dogs not helped by repurposed.
· UPDATE (JUNE 29, 2018) – Today, the FDA reissued an advisory that warns veterinarians and pet owners about the risk of accidental overdose for dogs prescribed Sileo.This prescription gel is given to dogs orally for the treatment of noise aversion. From May 2016-when Zoetis started marketing the product-through May 16, 2018, the FDA has received 54 adverse event reports involving Sileo.
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SILEO (dexmedetomidine oromucosal gel) is a synthetic alpha-2 adrenoceptor agonist. Each ml of SILEO contains 0.09 mg dexmedetomidine (equivalent to 0.1 mg dexme- detomidine hydrochloride). The chemical name is (+)-4-[1-(2,3-dimethylphenyl) eth- yl]-1H-imidazole monohydrochloride.
SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival diseases that could have an effect on SILEO’s absorption. SILEO has not been evaluated for aversion behaviors to thunderstorms.
Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation.
Sileo has been approved by the FDA to help dogs with noise aversion. It is an alpha-2 adrenoceptor agonist that works, in part, by depressing activity in certain parts of the brain, which results in reduced anxiety levels, among other effects.
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An innovative way to treat noise anxiety in dogs. Introducing Sileo, a fast acting oromucosal gel that can be tailored to the timing and duration of the noise event.
A little over a year ago, a frantic gentleman zoomed into my clinic’s parking lot with a dog. As he crossed the threshold of the hospital, the dog took her last breath and expired. The man was.
Sileo is a new drug on the market to help dogs stay calm during thunderstorms, fireworks, and similar events with loud noises.